To generate a cytopathic effect, the catalytic A1 subunit of cholera toxin (CT) must be separated from the rest of the toxin.Protein disulfide isomerase (PDI) is thought to mediate CT disassembly by acting as a redox-driven chaperone that actively unfolds the CTA1 subunit.Here, we show that PDI itself unfolds upon contact with CTA1.The substrate-in

The gap in Kenya between need and treatment for mental disorders is wide, and private providers are increasingly offering services, funded in part by private health insurance (PHI).Chiromo, a 30-bed psychiatric hospital in Nairobi, forms part of one of the largest private psychiatric providers in East Africa.The study evaluated the effects of insur

A current challenge is to develop computational approaches to infer gene network regulatory relationships based on multiple types of large-scale functional genomic data.We find that single-layer feed-forward artificial neural network (ANN) models can effectively discover gene network structure by integrating global in vivo protein:DNA interaction H

Uncertified rural practitioners Helmet Accessories (URPs) without formal medical qualification occupy an indispensable yet dangerous position in the rural health care system in India.The low cost, close proximity, and higher health hazards in rural areas along with the inability of established health-care setups to fulfill existing demands have fav

This article studies how Small and Medium Enterprises (SMEs) operating in emerging economies implement adaptative strategies to respond to constant changes in demand and global uncertainties, such as those stemming from the current SARS-COV2 pandemic.In this study the knowledge management capabilities used by SMEs in the craft beer sector Dark Hors